DNA replication
| PAG Title | DNA replication |
| PAG ID | WAG000620 |
| Type | P |
| Source Link |  KEGG |
| Publication Reference | NA |
| PAG Description | A complex network of interacting proteins and enzymes is required for D replication. Generally, D replication follows a multistep enzymatic pathway. At the D replication fork, a D helicase (DB or MCM complex) precedes the D synthetic machinery and unwinds the duplex parental D in cooperation with the SSB or RPA. On the leading strand, replication occurs continuously in a 5 to 3 direction, whereas on the lagging strand, D replication occurs discontinuously by synthesis and joining of short Okazaki fragments. In prokaryotes, the leading strand replication apparatus consists of a D polymerase (pol III core), a sliding clamp (beta), and a clamp loader (gamma delta complex). The D primase (DG) is needed to form R primers. Normally, during replication of the lagging-strand D template, an R primer is removed either by an Rse H or by the 5 to 3 exonuclease activity of D pol I, and the D ligase joins the Okazaki fragments. In eukaryotes, three D polymerases (alpha, delta, and epsilon) have been identified. D primase forms a permanent complex with D polymerase alpha. PC and RFC function as a clamp and a clamp loader. FEN 1 and Rse H1 remove the R from the Okazaki fragments and D ligase I joins the D. |
| Species | Homo sapiens |
| nCoCo Score | 9,777 |
| Base PAG ID | WAG000620 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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